Adaptogenic PCT by Anabolic Labs
- Anti-Estrogen Compound
- Upregulate Androgen Receptor Regulation
Dihydrocoumarin, (2E)-3,7-Dimethyl-2,6-octadien-1-ol, 7,8 Benzoflavone, Maral Root and Daidzein
Anabolic Labs Adaptogenic PCT has been formulated to be an anti-estrogenic and anti-catabolic Adaptogen. It contains nature-identical compounds, which are specially formulated to potentially block the conversion of testosterone to estrogen.
Dihydrocoumarin is a naturally occurring (in this case nature identical) compound found in Sweet Clover. Research has shown that dihydrocoumarin could inhibit the human NADþ-dependent deacetylase SIRT1 and observed that DHC induced a concentration-dependent inhibition of SIRT1. SIRT1 is a repressor of anabolic and androgenic activity and inhibits DHT mediated transcription. Thus by inhibiting SIRT1 and SIRT2, anabolic activates are promoted. SIRT1 inhibition also upregulates androgen receptor expression.
2E)-3,7-Dimethyl-2,6-octadien-1-ol is an estrogen receptor targeting agent, and acts as an anti-estrogen compared with β-estradiol. It has a higher binding affinity for the receptor so it actually displaces β-estradiol from the receptor. β-oestradiol influences adipose tissue production. The compound has also shown to confer anti-depressant like activity in chronic stress conditions.
7,8 Benzoflavone, is an analogue of a naturally occurring flavone which has been reported to have strong estrogen receptor antagonistic behaviour, but low bioavailability due to poor solubility.
Maral root is an adaptogen and a class of compounds reported to increase tolerance to stress. The extract contains a range of phytonutrients including 20-hydroxy- ecdysterone, and a number of aryl-hydrocarbon receptor agonists known to be anabolic. Maral root has demonstrated a wide range of adaptogenic benefits having been used as a cardiac tonic, antioxidant, immune stimulant and nervine with antitumor and hepatoprotective properties.
Daidzein is a polyphenol which exhibits activity at both the androgen receptor and its associated proteins for a net anabolic effect. It is both anabolic and unlike steroids, may increase testosterone through the increased mRNA levels of StAR and 3β-HSD-1
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